Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites
Article Abstract:
A new basic helix-loop-helix (bHLH) protein called paraxis has been found in mouse embryos. Its HLH sequence is 89% homologous to another bHLH protein called scleraxis, but diverges in its amino and carboxyl termini. These proteins are expressed on both sides of the neural tube during the early development of the embryo and control the development of somites and the dermamyotome and sclerotome. Paraxis is initially expressed in the dermamyotome and sclerotome, but is eventually localized in the dermamyotome only. At that point, scleraxis is produced in the sclerotome.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis
Article Abstract:
A cloned basic helix-loop-helix protein (bHLH), designated as Dermo-1, was examined to determine the role of tissue-specific bHLH proteins in dermal cell expression, determination and differentiation. Dermo-1 was strongly expressed in the sclerotome and dermatome of somites and in the limb buds. However, expression was reduced as differentiation of cells proceeded and became localized to the perichondrium. These results suggest that Derm-1 plays a role as a regulator of gene expression in dermis development.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development
Article Abstract:
The expression pattern of eHAND, a novel protein gene in mice, is described. The expression pattern is different from that of other class B helix-loop-helix (bHLH) genes, and the gene may contribute to the formation of extraembryonic tissues, heart and neural crest derivatives. eHAND may express a new subclass of class B bHLH proteins because of the low sequence identity of eHAND with other bHLH family members as well as its unique expression pattern during development.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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