Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1

Article Abstract:

The isolation and sequencing of two overlapping cDNA clones that cover the entire coding region of Pax9 reveal a high resemblance even outside the paired box. The Pax1 gene is deleted in undulated short-tail mouse embryos without affecting expression of Pax9, indicating that Pax9 is independent of Pax1. However, the gene expression of Pax9 in the vertebral column depends on the notochord. This further indicates that both Pax9 and Pax1 function in parallel during the morphogenesis of the vertebral column.

Mice, Mice (Rodents), Gene expression, Morphogenesis, Spine

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Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities

Article Abstract:

Mice lacking the Pax9 gene have been generated in order to analyze the function of the gene, a member of a transcription factor family active in mammalian development and organogenesis in vivo. Pax9 has been shown to be necessary for development of various organs and skeletal parts. The Pax9-deficient mice have neither pharyngeal pouch derivatives nor teeth. They also show limb and craniofacial abnormalities. It appears that Pax 9 has a role in establishing the inductive capacity of the tooth mesenchyme.

Physiological aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Mice, mutant strains, Mutant mice, Cell differentiation, Thymus, Thymus gland, Skeleton, Parathyroid glands, Palate

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Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation

Article Abstract:

A study was conducted to identify Pax9 as a marker for prospective tooth mesenchyme prior to the initial morphological evidence of odontogenesis. The sites of Pax9 expression in the mandibular arch are positioned by the combined activity of two signals. The findings indicate that a combination of two different types of signaling molecules produced in wide but overlapping domains determines teeth position.

Binding sites (Biochemistry), Active sites (Biochemistry), Dentinogenesis

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