Phosphorylation and localization of replication protein A during oogenesis and early embryogenesis of Drosophila melanogaster

Article Abstract:

Multiple phosphorylated forms of Drosophila melanogaster Replication Protein A (DRP-A) have been found during oogenesis and in single embryos during the syncytial nuclear divisions of embryogenesis. The phosphorylated forms are regulated depending on cell cycles and developmental stages, with a specific mode of regulation in the early embryonic stages. During interphase DRP-A is confined to the nucleus, but it becomes delocalized during mitosis. These observations can be further explored directly in vivo by using the well-known genetics of Drosophila to determine the role of DRP-A in DNA metabolism.

Analysis, Chromosome replication, Phosphorylation, Oogenesis

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Essential and neural transcripts from the Drosophila shaking-B locus are differentially expressed in the embryonic mesoderm and pupal nervous system

Article Abstract:

Studying the giant fibre system (GFS) is a way to study one of the key issues of developmental neurobiology, namely, how cells build the synapses that are the basis of neuronal circuits. Another way is to study the defects in behavioral mutants. Some flies carrying certain shak-B alleles have abnormalities in some of the synapses of the GFS. The shak-B gene has two very different roles in development, which are tested and discussed here.

Embryology, Animal embryology

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Molecular and genetic analysis of the Drosophila mas-1 (mannosidase-1) gene which encodes a glycoprotein processing alpha 1,2-mannosidase

Article Abstract:

The mannosidase-1 gene (mas-1) in Drosophila melanogaster is very similar to the alpha1,2-mannosidases in yeast and mammals. These enzymes process glycoproteins by removing mannose. Mutations in the mas-1 gene produce embryos that have defects in the peripheral nervous system, wings and eyes. However, the embryos are still viable, indicating that there may be other mannosidases involved in embryo development.

Glycosylation

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