Plexin A is a neuronal semaphorin receptor that controls axon guidance

Article Abstract:

The genes encoding two Plexins in Drosophila were cloned and examined. Genetic and biochemical evidence was found supporting the notion that Plexin A is a neuronal receptor for the transmembrane class I Semaphorins Sema 1a and 1b. Moreover, it was demonstrated that Plex A has an influence on axon guidance. Mutations in PlexA involved the same phenotypes found in previous studies. The genetic interrelationship between the two loci was consistent with their functioning in the same signalling pathway. These suggest that Plexins act as neuronal Semaphorin receptors and govern relevant features of axon guidance.

Membrane proteins, Neurotransmitter receptors

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Netrin-1 is required for commisural axon guidance in the developing vertebrate nervous system

Article Abstract:

Netrin-1 is a large soluble protein that directs the circumferential axonal projections in vertebrates during the development of the vertebrate nervous system. The protein is expressed in the floor plate for directing the formation of the fimbria, hippocampal commissure, corpus callosum and anterior commissure. Furthermore, embryonic mice with deficient netrin-1 proteins due to the mutation of the netrin-1 allele exhibited defective spinal cord, hippocampal commissure and anterior commissure development.

Physiological aspects, Mice, Mice (Rodents), Genetic transcription, Transcription (Genetics), Developmental neurology, Neurogenetics, Spinal cord

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Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family

Article Abstract:

Research has been conducted on long hippocampal axon branche prunning. Resuts demonstrate that hippocampal neurons respond to semaphorins via retracting axon branches.

United States, Cell death, Cell research, Cytological research, Hippocampus (Brain)

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