Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene

Article Abstract:

Mice without the Orthopedia (Otp) gene have progressive impairment of developing hypothalamus neuroendocrine cell lineages. New data show that likely Otp and Sim1 act in parallel and are necessary to maintain Brn2 expression, which is necessary for neuronal cell lineages that secrete oxytocin, arginine vasopressin and corticotropin-releasing hormone. Sim1 is a bHLH-PAS transcription factor. It directs terminal differentiation of the supraoptic, periventricular, and anterior perventricular cells. Otp is a very conserved homeodomain-containing factor.

Canada, Hypothalamus, Homeobox genes, Cell proliferation, Neuroendocrinology, Pituitary gland

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Targeting disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

Article Abstract:

Disruption of Fgf8, a targeted disruption which causes failure of cell migration in the gastrulating mouse embryo, is discussed. Fgf8 is a gene shown to be required for gastrulation and it has been shown that FGF8 and/or FGF4 signaling is required for cell migration away from the primitive streak.

Developmental genetics, Gastrulation, Epithelium

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Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survivial and patterning of the first branchial arch

Article Abstract:

Results demonstrate that FGF8 functions as an epithelial signal mediating the outgrowth and patterning of first branchial arch from early stages of embryogenesis as shown by Cre/loxP technology.

Physiological aspects, Striated muscle, Cellular signal transduction, Endothelin, Agnathia

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