RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences
Article Abstract:
It has been shown that RAG1/RAG2 can mediate resolution of transposition intermediates using either of two pathways with two possible consequences. Disintegration is the favored resolution path where magnesium concentrations are high as is the case in mammalian cells. Disintegration removes transposed donor DNA from the intermediate. In the other case RAG1/2 catalyzes hairpin formation on target DNA beside transposed recombination signal sequences (RSS) ends in a way that is consistent with a model that leads to chromosome translocations.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells
Article Abstract:
The polymeric immunoglobulin receptor (plgR) has been found to move pneumococci across human nasopharyngeal epithelial cells. The human phgR (hplgR) binds to a major Streptococcus pneumoniae adhesin, CbpA. Expression of phlgR in nasopharnygeal cells and MDCK cells enhances pneumococcal adherence and invasion greatly.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
Article Abstract:
Plexin-neuropilin(NP)-1 complexes, which form functional semaphorin-3A receptors, are discussed. Physiologic Sema3A receptors are made up of NP-1/plexin complexes. To explore the relationship between two semaphorin-binding proteins, an effort was made to characterize any molecular interactions between NP and plexin.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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