Regulation of the Aspergillus nidulans penicillin biosynthesis gene acvA (pcbAB) by amino acids: implication for involvement of transcription factor PACC

Article Abstract:

The presence of amino acids has different effects on both Aspergillus nidulans penicillin production and expression of the biosynthesis genes acvA (pcbAB) and ipnA (pcbC). Amino acids which negatively affect the expression of acvA-uidA and ipnA-lacZ gene fusions resulted in lower ambient pH during cultivation of the fungus. Results also indicate that the transcription factor PACC regulates the expression of acvA. Regulators aside from PACC appear to be involved, since the repressing effect of lysine and methionine on acvA expression was even greater in one of the detection clones and the pacC5 mutant strain.

Genetic transcription, Transcription (Genetics), Structure-activity relationships (Pharmacology), Amino acids, Amino acid structure-activity relationships

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Protein kinase C (PKcA) of Aspergillus nidulans is involved in penicillin production

Article Abstract:

The inhibition of protein kinase C (pkc) activity in Aspergillus nidulans led to cytoplasmic localization of an AnBH1-enhanced green flurorescent protein (EGFP) fusion protein is shown. The involvement of pkc in penicillin biosynthesis is also interesting in light of the fact that in the yeast saccharomyces cerevisiae, pkc plays a major role in maintaining cell integrity

Science & research, Protein kinases, Bacterial proteins

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Cloning and characterization of an Aspergillus nidulans gene involved in the regulation of penicillin biosynthesis

Article Abstract:

An Aspergillus nidulans gene involved in regulation of penicillin biosynthesis has been cloned and characterized using complementation with a genomic cosmid library. Analysis of the suAprgA1 gene in the prgA1 mutant showed no mutation in the gene and no unusual transcription of it, suggesting that the suAprgA1 gene suppresses the prgA1 mutation.

Germany, Statistical Data Included, Fungi, Cytochemistry, Cellular control mechanisms, Cell regulation

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