Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data

Article Abstract:

The maximum-likelihood-binomial (MLB) method has been extended to multipoint linkage analysis. The general outline of hidden Markov models is used. A large simulations study has been carried out to study power of robustness of the MLB method in multipoint analysis of varying affected-sibship samples.. The method is based on the binomial distribution of parental marker alleles in affected offspring. The MLB method is compared to the maximum-likelihood-score (MLS) method as used in MAPMAKER/SIBS.

Germany, Methods, Evaluation, Software, Mathematical models, Analysis of variance, Genetics, Statistical software

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Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33

Article Abstract:

Blood infection levels of Plasmodium falciparum, an organism that causes malaria in humans, are linked to chromosome 5q31-q33. The existence of complex genetic factors that control P. falciparum blood infection levels has been demonstrated through study of an urban population in Burkina Faso. From 34 families, 153 siblings were subjected to sib-pair linkage analyses between blood infection levels and chromosome 5q31-q33. Linkage of parasitemia to D5S393 and to D5S658 was found.

Subsaharan Africa, Burkina Faso, Health aspects, Infection, Physiological aspects, Malaria, Plasmodium falciparum, Linkage (Genetics), Sub-Saharan Africa

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Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene

Article Abstract:

Infection levels and severe hepatic fibrosis in Schistosoma mansoni infection are discussed relative to a segregation analysis performed in 65 Sudanese pedigrees from one village. The condition is regulated by a major locus linked closely to the interferon-gamma receptor gene. Why so few infected persons present with severe disease in endemic regions such as Sudan has been unclear.

Sudan, Statistical Data Included, Liver diseases, Chromosome mapping, Schistosomiasis, Fibrosis

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