SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions?
Article Abstract:
The study of the SWI and SNF genes from Saccharomyces cerevisiae has been focused on the assumption that their gene products and other related proteins, can destabilize the nucleosome structure of chromatin which in turn, facilitates the binding of the transcription factors to chromatin. SWI2 and SNF2 have been found to be identical thus, designated as SWI2/SNF2. The results of various studies on SWI2/SNF2 have indicated that these factors may function as ATP-driven motors that translocate along DNA and destabilize protein-DNA interactions via the 'spooling' mechanism.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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The 'dark side' of chromatin remodeling: repressive effects on transcription
Article Abstract:
Chromatin remodeling and its repressive effects on transcription are discussed in this review article. Recent studies that indicate that ATP-driven chromatin remodeling factors facilitate not only transcriptional activation, but also repression, are described. Both chromatin remodeling and nucleosome assembly are required for proper regulation of gene expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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The many faces of chromatin remodeling: SWItching beyond transcription
Article Abstract:
Research findings on chromatin remodeling are discussed in the context of processes other than transcription such as homologous recombination, DNA-repair, mitotic sister chromatid segregation, histone deacetylation, and maintenance of DNA methylation status in eukaryotic cell nucleus.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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