Sensors and signals: A coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
Article Abstract:
The functional consequences of molecular sensor and molecular adaptor actions of corepressor/coactivator complexes in integrating signal dependent programs of transcriptional responses at the molecular level are reviewed. This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Article Abstract:
Signal- and gene-specific repression of transcriptional responses initiated by engagement of toll-like receptors (TLR) 3,4, and 9 in macrophages is reported. The glucocorticoid receptor (GR) represses a large set of functionally related inflammatory response genes by disrupting p65/interferon regulatory factor (IRF) complexes required for TLR4- or TLR9-dependent, but not TLR3-dependent, transcriptional activation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway
Article Abstract:
The occurrence of specific interactions between prostate cancer cells and macrophages in most prostate cancers is discussed. The interactions mediate a switch in function of selective androgen receptor antagonist/modulators (SARMs) as agonists and activate a functional program of specific proinflammatory signals causing dismissal of the N-CoR holocorepressor complex from AR.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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