Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA
Article Abstract:
Research has been conducted on the biological consequences of DNA methylation mediated by the protein factors containing conserved methyl-CpG binding domains (MBDs). The solution structure of the MBD of the human methylation-dependent transcriptional regulator MBD1 bound to the methylated DNA has been investigated and the results indicate that DNA binding causes the MBD1 loop to fold.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Nucleosome sliding via TBP DNA binding in vivo
Article Abstract:
Research has been conducted on the nucleosome obstructing transcription from the IFN-beta promoter. The mechanisms and the nature of the chromatin that remodels during IFN-beta gene activation in response to the virus infection have been investigated and the results indicate that this nucleosome slides in vivo exposing the initiation site.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBF(beta)
Article Abstract:
Research has been conducted on the core binding factor heterodimeric transcription factors. The crystal structures of the DNA AML1/Runx-1 Runt complexes have been investigated and the effect of the point mutations of CBF(alpha) related to the acute leukemias and cleidocranial dysplasia on DNA binding has been discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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