Specification of neuronal connectivity: ETS marks the spot

Article Abstract:

Experiments suggested a model in which a signal from the peripheral target induces the expression of particular ETS proteins in individual motor pools and subsets of sensory neurons. The sensory neurons extend their central axons ventrally and make specific connections with motor neurons in appropriate motor pools. However, no evidences had been presented that ETS proteins are required for the formation of specific connections between central sensory axons and target motor neurons. Still, some data suggested ETS proteins play a role in the specification of spinal circuits.

Nervous system, Proteins, Sensory receptors

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Motor neurons and neurofilaments in sickness and in health

Article Abstract:

An update of the research in neurofilaments and motor neurons is presented. Further examination must be made regarding neurofilaments' modulation in development, regeneration and maintenance of nerves. Their relations with other cytoskeleton elements, biochemistry and the etiology of various pathologies are also important. In addition, motor neurons' role in the disease of amyotrophic lateral sclerosis is under investigation. Some particularly relevant issues include the impact of molecular mechanisms and the regulation of proteins' gene expression.

Causes of

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Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

Article Abstract:

A study generates transgenic mice through a large genomic fragment which includes the human neurofilament heavy (NF-H) gene. A modest overexpression of NF-H cross-linkers is revealed to cause a progressive neuropathy which has the pathological properties of amyotrophic lateral sclerosis, such as neurological defects and abnormal neurofilamentous swellings with axonopathy and muscle atrophy. These features also partly arise from an impairment of neurofilament transport.

Genetic aspects, Genetically modified mice

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