Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

Article Abstract:

A study was conducted to determine the essential and nonessential roles of Stat5a and Stat5b proteins in the cytokine responses. Two mutant genes of mice were analyzed. Results revealed that the phenotypes associated with the disruption of the individual genes can be seen in Stat5a and Stat5b and that the Stat5 proteins have essentials and redundant roles in the cytokine responses related with growth hormone and prolactin.

Analysis, Physiological aspects, Mice, Mice (Rodents), Somatotropin, Prolactin

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Jak2 is essential for signaling through a variety of cytokine receptors

Article Abstract:

Research was conducted to examine the role of Jak2 in cytokine signaling. Results taken from a Jak2-deficient mice revealed the lethality of the absence of definitive erythropoiesis. Moreover, Jak2 was found to be unnecessary in the generation, functional differentiation and amplification of lymphoid progenitors. These factors indicated the critical, non-redundant role of the said kinase.

Protein tyrosine kinase, Protein-tyrosine kinase

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

Article Abstract:

Suppressor of cytokine signaling-3 (SOCS3) (CIS3/JAB2), essential to negative regulation of fetal liver erythropoiesis, is discussed. It is an SH2-containing protein and binds to the activation loop of Janus kinases, which inhibits kinase activity. Thereby it suppresses cytokine signaling. SOCS3 is Epo-independent and highly expressed in erythroid lineage cells in embryonic development.

United States, Japan, Genetic aspects, Liver, Developmental biology, Physiological regulation, Biological control systems, Stem cells, Embryology, Animal embryology, Hematopoiesis, Cell research, Cytological research, Erythropoiesis

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