Storage and release of neurotransmitters
Article Abstract:
Synaptic vesicles and secretory granules are the two classes of regulated secretory vesicles within nerve terminals. The exocytotic machineries operating in each type of secretory vesicles during development and synaptic activity are discussed. In addition, recent findings in vesicle packaging and formation, neurotransmitter release, membrane fusion and the evolution of secretory vesicles are presented. Much of the progress in the understanding of these processes were derived from approaches using in vitro reconstitution, reverse genetics and studies on parallels with better understood systems.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Quantal release of neurotransmitter and long-term potentiation
Article Abstract:
The Katz theory of neurotransmitter release views neurotransmitter as prepackaged in discrete quanta which are released from individual sites in an all-or-none fashion with each quantum released probabilistically and independently of the others. This theory has been extended into a mathematical description and has been widely accepted as the standard picture of transmitter release. A number of current issues and dissenting views regarding Katz theory of neurotransmitter release are presented. The related subject of long-term potentiation is also reviewed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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A function for the AP3 coat complex in synaptic vesicle formation from endosomes
Article Abstract:
Research was conducted to examine the reverse coating of synaptic vesicles in vitro. This study required the use of synaptic vesicle membrane proteins and a chemical reaction dependent on ARF, ATP and temperature. Moreover, the coat was made up of an adaptor protein 3 and heterotetrameric complex. Results showed the successful reconstitution of the membrane trafficking event using AP3.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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