Structure of an IkappaBalpha/NF-kappaB complex
Article Abstract:
A study was undertaken to describe the structure of the ankyrin domain of IkappaBalpha bound to a heterodimer of the transcription factor, NF-kappaB, having the Rel homology region (RHR) of p65 and the C-terminal (RHR-C) domain of p50. IkappaBs are a class of specific inhibitory proteins preventing nuclear translocation and DNA binding of the NF-kappaB. It was observed that the internal structures of the ankyrin repeats resembled each other with their sequences closely related. The interaction between IkappaBalpha and NF-kappaB possessed several patches each involving conserved number of residues.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker
Article Abstract:
The crystal structure at 2.6 Angstroms resolution of a 55 kDa fragment from the N terminus of the clathrin heavy chain is analyzed. The structure consists of the globular 'terminal domain' and the linker that joins it to the distal leg. The terminal domain is a seven-blade beta propeller that is suitable to interact with multiple partners, while the linker is an alpha-helical zigzag originating from the propeller domain. Based on these findings, it is suggested that this molecular structure may extend into the other parts of the clathrin leg.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Variation on an Src-like theme
Article Abstract:
This review examines the biological control circuits, their evolution and adaptability with respect to the structure and function of the component proteins. The proteins with their domain diversity and architecture are able to spring a vast combinatorial possibilities. Data suggest that the protein domains involved in a particular function are generally conserved for reuse without necessiating their reinvention.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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