Synaptonemal complexes from DNase-treated rat pachytene chromosomes contain (GT)sub n and LINE/SINE sequences
Article Abstract:
Cloning and sequencing of synaptonemal complexes from digested rat pachytene chromosomes revealed (GT)sub n repeats and 'long' and 'short' interspersed repetitive element (LINE/SINE) sequences. These repeats ranged between 100 to 500 base pairs long. Hybridization studies revealed that the SC-associated LINE fragments were significantly different from genomic LINE fragments. Tandem repetition of the (GT)sub n sequences suggested that the SC-associated DNA was selectively enriched with these sequences. Localization of the (GT)sub n and LINE sequences was also attempted, but was unsuccessful.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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A short chromosomal region with major roles in yeast chromosome III meiotic disjunction, recombination and double strand breaks
Article Abstract:
Addition of plasmids containing a fragment from the middle of Saccharomyces cerevisiae chromosome III right arm cause a twofoldenhancement of cis acting nondisjunction of chromosome III in the host yeast. The plasmid undergoes integration with the chromosome of the host yeast spontaneously in both normal and nondisjunctive meioses although more readily in the latter. The fragment from chromosome III apparently encompasses a 'hot spot' for recombination as proven by a strong signal for double strand breaks induced by meiosis.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
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Commitment to meiosis in Saccharomyces cerevisiae: involvement of the SPO14 gene
Article Abstract:
The SPO14 gene of Saccharomyces cerevisiae was mapped and sequenced. Results show that it follows Mendelian genetics and is localized to the right arm of chromosome XI. Mutants with the spo14 trait were not irreversibly committed to meiosis at the late stages of meiosis when wild-type cells have already been fully committed. Thus, SPO14 gene is thought to code for a factor involved in the coordinated induction of events in late meiosis. This coordinate induction could be the basis for the commitment phenomenon.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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