Targeted disruption of the p50 subunit of Nf-kappa-B leads to multifocal defects in immune responses
Article Abstract:
A study of the effects of ablation of the NF-kappa-B1 gene region that codes for the p50 subunit through a gene targeting program reveals normal expression of the binding sites for the p50 homodimer and NF-kappa-B by p50-absent-cells. These cells possess an immune system with multifocal defects in immune and non-specific responses but do not exhibit any developmental defects. Bacterial lipopolysaccharides do not evoke proliferation in basal and specific antibody production-deficient B cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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NF-kappaB: ten years after
Article Abstract:
NF-kappaB, the prototype of a family of dimeric transcription factors, was discovered in 1986. The family was made from monomers with approximately 300 amino-acid Rel regions which bind to DNA, interact with each other and bind the IkappaB inhibitors. Following the discovery of the prototype, researchers decided to meet regularly to keep updated on developments regarding the family. The first meeting was held in 1992 and the second in 1993. The latest was held in Madrid, Spain, in 1996.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein
Article Abstract:
The three-dimensional structure determination studies of the human TFIIB core domain (TFIIBc) by single, double and triple nuclear magnetic resonance spectroscopy, reveal the presence of two repeats of alpha helical folds that appear to give a two-fold symmetry to the molecule. There is a basic surface at the center which is essential for its function. The structure of TFBIIc resembles that of cyclin A, suggesting a link between transcription and cell cycle molecular mechanisms.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
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