Exit from mitosis: spindle pole power

Article Abstract:

This article discusses the process of eukaryotic mitotic cell cycle and the role of spindle fibers in facilitating segregation of replicated chromosomes. Mechanisms governing proper spindle positioning play a role in preventing premature exit of the dividing cell from mitotic process.

Japan, Genetic aspects, Eukaryotic cells, Cells (Biology), Eukaryotes, Cytokinesis

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Motor function in the mitotic spindle

Article Abstract:

This article discusses recent advances made with regard to the role of mitotic spindle in mitosis. Results describe a chromosomally localized motor termed Xenopus kinesin-like DNA binding protein which aligns chromosomes on the spindle. Data indicate that the motor gets degraded before the chromosomes segregate during anaphase.

DNA binding proteins

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The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis

Article Abstract:

Research shows that the regulation of spindle disassembly by the AAA-ATPase Cdc48/p97 occurs by modulating microtubule dynamics and bundling during mitosis. The absence of p97 and the adapter protein Ufd1-NpI4 leads to microtubules arrangement in monopolar spindles in Xenopus.

Switzerland, Cellular control mechanisms, Cell regulation, Microtubules

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