The Tpr protein: linking structure and function in the nuclear interior?
Article Abstract:
The Tpr protein, a 262-kD filamentous protein, may link structure and function in the nuclear interior. Nuclear matrix proteins seem to be components of RNA metabolism instead of skeletal proteins, based on recent studies. It would perhaps be well to relax expectations of what a nuclear matrix must be and how rigid it is. Interchromosomal channels and pore complex-associated intranuclear filaments in a matrix model would unify transcription at surfaces of chromosomes, nuclear transport and mRNA metabolism through common structural components. It appears that pore-complex-associated intranuclear filaments in the interchromosomal channel network are a model for a nuclear matrix. Functions of Tpr are not yet well understood. It seems Tpr plays a role in intranuclear transport. Tpr has potential as a part of an interchromosomal channel nuclear skeleton.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links
Article Abstract:
Signals transmitted in both directions across endothelium regulate remodeling of blood vessel architecture in adults. It may be that inability of endothelium to combine hemodynamic events efficiently with production of the gaseous second messenger, nitric oxide (NO), adds to abnormal vascular remodeling in numerous diseases. Lack of linking between eNOS and disease phenotypes analyzed so far makes it appear that there is not a simple model in which eNOS mutations cause heritable vascular disease directly, but it may be that further study of identified polymorphisms will show vascular phenotypes of significance. Breeding of eNOS knockout mice to ApoE (ital) knockout mice would be helpful in testing the importance of NO in progression of atherosclerotic lesions and vessel adaptation.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
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Having it all
Article Abstract:
The article describes the achievement of Dorothy Warburton in human cytogenetics.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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