The bare lymphocyte syndrome: molecular clues to the transcriptional regulation of major histocompatibility complex class II genes
Article Abstract:
The bare lymphocyte syndrome (BLS), a rare severe combined immunodeficiency that is autosomal recessive, is discussed in relation to molecular clues about major histocompatibility complex (MHC) class II genes and their transcriptional regulation. Complementation group A cells have defects in the class II transactivator (CIITA), deficiencies in the complementation groups B,C, and E exist, and CIITA and the regulatory-factor X (RFX) complex are integral parts of MHC class II expression.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
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Insights from model systems: genes that regulate eosinophilic inflammation
Article Abstract:
Insights into genes that regulate eosinophilic inflammation are discussed with information about the acquisition of those insights from model systems. The role of interleukin (IL)-5 in eosinophil differentiation, the regulation of adhesive interactions in circulating neutrophils and eosinophils, and roles of chemokines in eosinophil chemotaxis into tissues are all of importance.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
User Contributions:
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