The effect of constraint on the rate of evolution in neutral models with biased mutation
Article Abstract:
The neutral theory of evolution implies an inverse relationship between the importance of a gene and its rate of evolution. However, there are instances when neutral alleles may evolve at an increased rate. This is shown in the analysis of mutation patternsinvolving codon bias, wherein the number of potential neutral alleles are reduced. Calculating for the average rate of evolution under these conditions, it is shown a sequence with fewer potential alleles can evolve faster than one with more potential neutral alleles. Furthermore, the average rate of evolutionover a set of three-allele sites is greater than that at a four-allele site.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Reply to Richard R. Hudson
Article Abstract:
The elucidation of a species phylogeny should not be attempted unless the gene genealogy can be inferred with confidence. In addition to this limitation, the use of the infinite allele model to approximate the distribution of the frequency of allele A at node 1 may introduce errors. However, the basic results of the analysis may be obtained without using the infinite allele model. If there are two alleles segregating without mutations, P(T) = (2 - e raised to the negative T/2 + e raised to the negative T) can be obtained for M = 0.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Differentiating between selection and mutation bias
Article Abstract:
A testing model derived from the MacDonald-Kreitman test, itself a derivation of the HKA test, is used to examine the effects of mutation from selection biases. A comparison of the pattern of polymorphism to the pattern of substitution is conducted by first dividing any two groups of nucleotides at each site. The test could result in the proportion of preferred substitutions to be greater than, less than or equal to the proportion of preferred mutations.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Effects of nutrients on specific growth rate of bacterioplankton in oligotrophic lake water cultures. Effect of substrate and cell surface hydrophobicity on phosphate utilization in bacteria
- Abstracts: The frequency of conspecific brood parasitism and the pattern of laying determinancy in Yellow-headed Blackbirds
- Abstracts: The effects of parental quality and timing of breeding on the growth of nestling Thick-billed Murres. Breeding and post-breeding habitat use by forest migrant songbirds in the Missouri Ozarks
- Abstracts: The effect of supplemental food on body condition and the timing of reproduction in a cooperative breeder, the Florida Scrub-Jay
- Abstracts: Mammalian origins of replication. On the nature of origins of DNA replication in eukaryotes. Accessory protein function in the DNA polymerase III holoenzyme from E. coli