The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia
Article Abstract:
A study was conducted on the pattern of the ligand KL in newborn gonads to determine the function of the tyrosine kinase receptor c-kit and KL in the postnatal development of germ cells. Results revealed high KL expression in testes, regardless of age, while in ovaries, expression was low at birth but gradually increased with age. The membrane-bound type of KL was found to be predominant in male gonads, while both forms were found to be present in those of females. Large KL amounts were detected in developing oocytes, while KL expression intensity in the testis dropped as spermatogenic cells increased. These suggest that KL is important for oocyte grwoth and in type A spermatogonia proliferation and differentiation.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
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The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles
Article Abstract:
A study was conducted on the kit ligand (KL) coding region in Steel Panda (Sl(super pan))/Sl(super pan) homozygotes to elucidate the molecular basis of the Sl(super pan) mutation. Results revealed that in several tissues, KL RNA expression dropped to 60% and 20% in heterozygous and homozygous mutant mice, respectively, indicating the the mutation's alteration of KL RNA expression is tissue-specific. In the gonads of Sl(super pan)/Sl(super pan) mice, reduced KL levels lowered germ cell number below normal and arrested ovarian follicle development. Spermatogonial development, however, was only slightly affected.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
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A discrete LINE-1 transcript in mouse blastocysts
Article Abstract:
A study was conducted on LINE-1 (L1) transcripts in mouse oocytes and early embryos to determine whether a functional L1 RNA is expressed at a particular stage of the germ cell life cycle, in accordance with the retrotransposon model for L1 element generation. Results revealed an abundance of an 8-kb L1 transcript in mouse blastocysts not detected in oocytes. This transcript was found to be polyadenylated, sense strand and spanned the 5' end of two open reading frames. It was suggested that retrotransposition takes place during or around the blastocyst stage.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
User Contributions:
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