The generation of antibody diversity through somatic hypermutation and class switch recombination
Article Abstract:
A second wave of antibody diversification occurs through somatic hypermutation (SHM) or gene conversion (GC) of the V region to generate high-affinity antigen binding sites. The biochemical mechanisms of CSR (Class Switch Recombination) and SHM (Somatic Hyper Mutation) are discussed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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RGS 10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca.sup.2+ .sub.i]
Article Abstract:
The osteoclast differentiation that leads to bone diseases like osteoporosis and rheumatoid arthritis is hampered by mutation of regulator of G-protein signaling 10 (RGS10). It leads to prevention o Calcium ion fluctuation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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Exploiting quantitative trait loci in gene discovery
Article Abstract:
The loci that contributes to the difference between the parents are referred to as quantitative trait loci(QTL). QTL or mutation serve as a tool in gene discovery.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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