The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors

Article Abstract:

Warts, encoding large tumor suppressor (Lats) and melted encoding a PH-domain protein, play opposite roles in defining the yR8 or pR8 fates. By interacting antagonistically at the transcriptional level, they form a bistable loop that insures a robust commitment of R8 to a single fate, without allowing ambiguity, thus representing an unexpected postmitotic role for genes controlling cell proliferation.

Drosophila, Tumor suppressor genes, Cell research, Cytological research, Warts, Tumour suppressor genes

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Homothorax switches function of Drosophila photoreceptors from color to polarized light snsors

Article Abstract:

Results demonstrate that homothorax's homeodomain transcription factor is essential for the development of dorsal rim area. Further, homothorax is involved in the adaptation of photoreceptors to the polarization-sensitive dorsal rim area fate. Data indicate that the iroquois complex and the wingless pathway are involved in the induction of homothorax expression.

Switzerland, Genetic transcription, Transcription (Genetics), Homeobox genes, Photoreceptors, Visual discrimination

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Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates

Article Abstract:

A study to show that the larval eye is composed of 12 photoreceptors (PRs), four of which express blue-sensitive rhodopsin5 (rh5) while the other eight contain green-sensitive rh6, is presented. Results reveal that even though the larval PRs and adult R8 PRs express the same rhodopsin (rh5 and rh8), they use very distinct mechanisms for their specification.

Gene expression, Rhodopsin, Larvae

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