The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation
Article Abstract:
A study was conducted to identify the genes involved in nephrogenesis or kidney development by isolating mRNA species expressed in the kidney through subtractive hybridization. The results revealed a marked expression of 14-3-3 gene family in the mesenchyme than elsewhere in the embryo. However, the level of expression varied as the mesenchyme differentiated into bone, cartilage, myotome-derived muscle and the presumptive muscle layer of the gut and kidney. These suggest that 14-3-3 gene plays a key role in neural development during the early stages, but loses the function at the onset of tissue differentiation.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Coordinated expression of Abd-B subfamily genes of the HoxA cluster in the developing digestive tract of chick embryo
Article Abstract:
A study was conducted to examine expression domains of Abd-B subfamily genes of the HoxA cluster, Hoxa-9, -10, -11 and -13, in the chicken embryonic alimentary tract. The analysis of expression patterns revealed high concentration in the visceral mesodermal. Expression occurred at three stages, early, middle and late, with the expression domains becoming exclusive and restricted to certain regions. At the later stages, development of the hindgut gives rise to the ceca and expression of the genes regulate the budding process in the region.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Limb bud mesenchyme permits seminiferous cord formation in the mouse fetal testis but subsequent testosterone output is markedly affected by the sex of the donor stromal tissue
Article Abstract:
A study was conducted to analyze the molecular mechanisms underlying gonadal formation in male mice. Hindlimb buds were immersed in a vital stain and grafted to a male gonad primordia and cultured for 96 hours. Analysis of the Sertoli and Leydig cells in the fetal gonads revealed migration of the hindlimb stromal cells to the genital ridge to allow seminiferous cord formation. There was also high testosterone production in the hindlimb in males compared to females.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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