The recent origin of allelic variation in antigenic determinants of Plasmodium falciparum
Article Abstract:
A commentary made by Austin L. Hughes et al on the results of a study conducted on the ancient polymorphism of the malaria parasite Plasmodium falciparum cited three arguments. First was the abundance of nucleotide polymorphisms in the circumsporozoite protein. Second was the fact that P. falciparum genomes were AT rich. Third was the study made on loci that coded enzymes and other proteins. However, results of the first study were based on 10 loci located on at least six chromosomes. Therefore, it is reiterated that there was no room for error in the original conclusion.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1998
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Models of host-parasite interaction and MHC polymorphism
Article Abstract:
Studies which assume that the selection process for major histocompatibility complex (MHC) loci is frequency-dependent rather than overdominant are based on earlier models of host-parasite interaction. However, these models are based merely on assumptions which do not necessarily explain such relationships. Thus, they may not hold in actual representation. To effectively model MHC, basic features of its functions must be included. Analysis shows that MHC-related resistance to infectious diseases is semi-dominant, if not totally dominant.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Ancient polymorphism and the hypothesis of a recent bottleneck in the malaria parasite Plasmodium falciparum
Article Abstract:
Stephen M. Rich et al concluded their experiment with the findings that the genealogy of the human malaria parasite Plasmodium falciparum began with a single haploid genotype that existed between 22,500 and 55,500 BC. The result was not in agreement with other studies that revealed that genetic polymorphisms of P. falciparum has been in existence for millions of years. They also ignored results of other researches made on polymorphisms of P. falciparum at loci encoding surface proteins.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1998
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