The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores
Article Abstract:
Antibodies to Bacillus anthracis and anthrax toxin components and their role in inhibiting early stages of infection by anthrax spores have been studied. Studies were carried out to find out whether anti-protective antigen (PA) antibody (Ab)-containing preparations stimulated spore uptake by phagocytes and suppressed germination of spores in vitro. Anthrax Vaccine Absorbed (AVA)- and PA-immune sera from several species enhanced phagocytosis by murine peritoneal macrophages of spores of two virulent vaccine strains. The anti-PA Ab-specific immunity induced by AVA has been found to have antispore activity and may have a protective role in early stages of infection with the spores. Effective vaccines against anthrax have the PA component of anthrax toxins as the major protective immunogen.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2001
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Multiple effects on Clostridium perfringens binding, uptake and trafficking to lysosomes by inhibitors of macrophage phagocytosis receptors
Article Abstract:
Results reveal that the scavenger receptor and mannose receptor(s) mediate the phagocytosis of Clostridium perfringens and that the former shows greater binding of the bacteria. The binding and/or uptake of C. perfringens is fecilitated by complement receptor. Carbohydrate analysis of the bacteria shows the presence of mannose and glucuronic acid, which are involved in the binding of mannose and scavenger receptors, respectively.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2003
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Inverse relationship between pilus-mediated gonococcal adherence and surface expression of the pilus receptor, CD46
Article Abstract:
Results reveal that the involvement of CD46 pilus receptor in the pilus-mediated adherence of Neisseria gonorrhoeae to epithelial cells is not as critical as it once presumed to be as indicated by a negative correlation between CD46 surface expression and pilus-mediated adherence.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2001
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