The synthesis of the bacteriocin sakacin A is a temperature-sensitive process regulated by a pheromone peptide through a three-component regulatory system
Article Abstract:
A 23-amino acid peptide called Sap-Ph is a pheromone that regulates bacteriocin production in Lactobacillus sakei Lb706. The peptide is produced by the orf4 gene, which is part of the sap gene cluster.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2000
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Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics
Article Abstract:
Result demonstrate that plantaricin W bacteriocin belongs to a new family of lantibiotics as evidenced by their structural properties. Data show that the two-peptide bacteriocin exhibits a Plwz peptide containing 29 residues and a Plwbeta peptide containing 32 residues, which synergistically work in a 1:1 ratio.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 2001
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Analysis of the sakacin P gene cluster from Lactobacillus sake Lb674 and its expression in sakacin-negative Lb. sake strains
Article Abstract:
The sakacin P gene cluster from Lactobacillus sake Lb674 has six consecutive genes, sppK, sppR, sppA, spiA, sppT and sppE, which are transcribed in the same direction. The gene cluster is similar to other bacteriocin gene clusters from lactic acid bacteria. The production of sakacin P in Lb674 is regulated by a two-component system. The bacteriocin-negative Lb. sake strains Lb 706X and Lb790 have incomplete spp gene clusters. Deletion and frameshift mutation analysis indicates that sppK, sppT and sppE are necessary for synthesis of the antimicrobial peptide sakacin P in strain Lb706X.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1996
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