The transmission/disequilibrium test and parental-genotype reconstruction: the reconstruction-combined transmission/disequilibrium test

Article Abstract:

A method that uses prenatal-genotype reconstruction and corrects for the biases resulting from reconstruction has been developed. Results of an application of this method to a real data set and of a simuation study indicate the approach may increase power to detect linkage. A method for testing a marker for linkage with a disease has been proposed. It combines data from families with/without information about parental genotypes. It may be possible to reconstruct parental genotypes from genotypes of offspring for some families with no parental-genotype information. Treating a reconstructed family as if parental genotypes are typed can bring bias, however.

Measurement, Statistics, Genotype, Genotypes, Identification and classification, Allelomorphism, Alleles, Genetic code, Linkage (Genetics)

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Relationship estimation by Markov-process models in a sib-pair linkage study

Article Abstract:

It is proposed that multipoint methods for classification of pairs in a sib-pair genome be based on a Markov-process model of allele sharing on chromosomes. Results of sib-pair linkage studies might be less valid if a substantial number of putative sib pairs are not in fact sib pairs. Such methods will be used in a coming version of the S.A.G.E. computer software package.

Software, Genetic aspects, Mathematical models, Genetics, Brothers and sisters

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Similar abstracts:

• Abstracts: A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test

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