The tumor-suppressor function of E-cadherin

Article Abstract:

The tumor-suppressor function of E-cadherin, the loss of which closely parallels carcinogenesis, is discussed with evidence from genetics and cell-culture studies that indicate a possible role of E-cadherin/catenin adhesion complexes in carcinogenesis. Downstream signal changes E-cadherin-mediated cell adhesion may bring on in tumorigenesis and a connection that may exist between Wnt signaling and E-cadherin function are considered.

Austria, Sweden, Physiological aspects, Molecular biology, Metastasis, Cancer invasiveness, Cancer metastasis, Cell adhesion, Cytoskeleton, Tumor suppressor genes, Carcinogenesis

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Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia

Article Abstract:

A genomewide linkage scan is conducted on patients with anonychia, an autosomal recessive disorder, and the R-spondin 4 (RSPO4) gene is analyzed. The results have indicated that mesenchymal-epithelial interactions are crucial in nail development and anonychia is put on the growing list of congenital malformation syndromes caused by Wnt-signaling-pathway defects.

Chromosome abnormalities, Exon (Molecular genetics), Exons (Molecular genetics), Nail diseases

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A mutation in CCDC50, a gene encoding an effector of epidermal growth factor-mediated cell signaling, causes progressive hearing loss

Article Abstract:

The identification of a mutation in CCDC50 is described as the cause if hearing loss in the family by examining its expression pattern in mouse inner ear. CCDC50 encodes Ymer an effector of epidermal growth factor (EGF)-mediated cell signaling expressed in different organs.

Epidermal growth factor, Epidermal growth factors, Hearing loss

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