Transcriptional activation: risky business
Article Abstract:
Transcriptional activation is discussed in this perspective article. A promoter-bound transcriptional activator or group of activators can be envisioned recruiting components of the basal transcriptional machinery to the DNA, leading in time to the recruitment of RNA polymerase II and the beginning of gene transcription. With this side of the story, there is another half. Proper regulation of transcription necessitates polymerase initiates when and where it should and also stops initiating when it should. Many questions exist. Ability of basal transcriptional apparatus to mark activators gives an efficient way to limit activator function. Also it can make sure continuing transcription initiation at a promoter works with continuing synthesis and activation of transcriptional activators.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16
Article Abstract:
The crystal structure of the conserved core of the herpes simplex virus (HSV) transcriptional regulatory protein VP16 has been studied and a novel seat-like protein structure found. The structure of free VP16 seems to indicate that it has a disordered carboxy-terminal region that associates with Oct-1, HCF and DNA in the VP16-induced complex. Also there is apparently a structured region involved in virion assembly. Free VP16 seems to have a novel DNA-binding surface that can tell TAATGARAT VP16-response elements apart.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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H2B ubiquitylation in transcriptional control: A fact-finding mission
Article Abstract:
The histone monoubiquitylation (H2Bub1) influences the elongation phase of the gene transcription. The increased association of H2Bub1 with the FACT region achieves the active removal of dimers of FACT that promotes the transcriptional elongation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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