Tumor induction of VEGF promoter activity in stromal cells

Article Abstract:

Vascular endothelial growth factor (VEGF) promoter activation associated with normal wound repair is manifested in transgenic mice that express an engineered version of the A. victoria green fluorescent protein under the control of the human VEGF promoter by fluorescence developing at the wound margins. This fluorescence extends throughout the granulation tissue. VEGF is widely expressed in normal tissues, and it seems likely in principle that almost any cell type could act as a source for VEGF upon hypoxic or ischemic demand.

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alphaLbeta2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

Article Abstract:

The intracellular protein cytohesin-1 appears to be a regulatory factor for the alphaLbeta2 integrin, which is a heterodimeric integral membrane protein that mediates between cell interaction and matrix and specific cell counterreceptors. Functional and biochemical analyses of the protein show that it is homologous to the yeast SEC7 gene product and bears a pleckstrin homology domain. Results further indicate that individual PH domains in the protein are capable of discriminating between alternative targets.

Cell adhesion molecules, Membrane proteins

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PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus

Article Abstract:

Biochemical evidence indicates that a segment at the amino terminus of P-selectin glycoprotein ligand 1 (PSGL-1), where a sulfated tyrosine residue is located, controls P-selectin adhesion and P-selectin binding to mucin-like molecules. P-selectin binding is reduced in the presence of sulfation inhibitors and is completely eliminated when tyrosine in the amino-terminal residues is mutated to phenylalanine.

Lectins, Protein binding, Cell adhesion

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