Unified nomenclature for Eph family receptors and their ligands, the ephrins

Article Abstract:

The rapid identification of receptors and their ligands has led to growing attention being given to the subfamily of receptor protein-tyrosine kinases which is made up of receptors related to Eph, a receptor which is expressed in an erythropoietin-producing human hepatocellular carcinoma cell line. So far, it has been possible to identify 14 different receptors of this subfamily and eight different ligands in warm-blooded vertebrates. It is now recognized that there is a need to unify and systematize the way in which these ligands and receptors are named. The ligands will now be known as ephrins and the receptors as Eph receptors.

Cell receptors, Letter to the Editor

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TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family

Article Abstract:

Molecular biological techniques were employed to clone and characterize the rat telomerase protein component 1 gene (TLP1). The gene encodes a 2629 amino acid sequence that yield p240 and p230 TLP proteins. The results provided evidences that the TLP proteins are components of, or are closely related to the rat telomerase. It was also shown that p240 is modified to p230 in vivo and that p230 is the dominant form in telomerase-positive cells. These findings indicated that the modification of the TLP1 protein may regulate telomerase activity in vivo.

Usage, Cell culture, Tissue culture, Enzymatic analysis, Western immunoblotting, Western blot

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Jagged: a mammalian ligand that activates Notch1

Article Abstract:

Cell culture assay studies find that Jagged activates rat Notch1 expressed in myoblasts and prevents muscle cell differentiation. Jagged, a rat cDNA clone, encodes a ligand for the vertebrate Notch protein. Some invertebrate ligands for the LIN 12/Notch have amino acid sequences similar to those ofJagged. Gene expression patterns for Jagged overlap with those of Notch1, Notch2 and Notch3.

Physiological aspects, Muscle cells

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