cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
Article Abstract:
A study of the regulation of decapentaplegic (dpp) transcription in Drosophila imaginal discs by cAMP-dependent protein kinase (PKA) and hedgehog (hh) using genetic mosaics reveals that dpp expression is suppressed by PKA through a signaling pathway while the expression is retained by the opposing action of hh on this pathway. Cells without PKA activity exhibit ectopic expression of dpp in the anterior compartment of appendage discs and anterior to the morphogenetic furrow in the eye disc. dpp activity determines the ability of PKA-lacking cells to rearrange anterior patterns in appendages.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with Salvador and Warts
Article Abstract:
Research demonstrates that hippo gene regulates both cell proliferation and cell death in Drosophila. Results show that the gene codes for Ste-20 family protein kinase, which binds to and phosphorylates Salvador tumor suppressor protein. The absence of hippo gene leads to increased cyclin E biosynthesis, cell proliferation and reduced cell death.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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Tsc2 is not a critical target of Akt during normal Drosophila development
Article Abstract:
Signaling by insulin and target of rapamycin are both required for cell growth, but their interrelationships remain poorly defined. It was reported that Akt, an essential component of the insulin-powered pathway, stimulates growth by phosphorylating and inhibiting tuberous sclerosis complex 2 (TSC2).
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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