p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

Article Abstract:

Estrogen-/antiestrogen-regulated AF-2-dependent transcriptional activation was carried out with chromatin templates in vitro with purified full-length human estrogen receptor (ER). Whether or not purified human p300 can act as a transcriptional coactivator was studied. Without ligand-activated ER, p300 has little effect on transcription, but there is a synergistic effect when the two are together. ER shows dual functions in transcription initiation/reinitiation in two phases. Transcription activation by ligand-activated ER and p300 are cooperative in increasing efficiency or productive transcription initiation. Then ER promotes reassembly of the transcription preinitiation complex.

Proteins, Genetic regulation, RNA polymerases, Cell receptors, Estrogen, Molecular genetics, Estrogen receptors

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Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

Article Abstract:

The application of Trabid as a new positive regulator of the Wnt-induced transcription and signaling in mammalian and Drosophila cells is discussed. Trabid is shown to exhibit a preference towards the binding and cleaving of the K63-linked ubiquitin chain, which is extremely important during the transcription.

Science & research, Genetic aspects, Drosophila, Animal embryology, Ubiquitin-proteasome system

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