A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
Article Abstract:
The effect of chemically synthesized small interfering RNAs (siRNAs) on mammalian double-stranded RNS (dsRNA)-activated signaling pathways is analyzed to find out the basis of the nonspecific activities. The results help in enabling the rational design of siRNAs that avoid nonspecific effects or, alternatively, that induce bystander effects to potentially enhance the efficacy of siRNA-based treatments of viral infections or cancer.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Taming ricin toxin
Article Abstract:
Ricin is a potent toxin and its cytocidal properties are exploited in cancer treatment. A single point mutation in ricin toxin can eliminate vascular leak syndrome without compromising the toxin's enzymatic action.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: cobA, a red fluorescent transcriptional reporter for Escherichia coli, yeast, and mammalian cells. Prospects for the use of nuclear transfer in human transplantation
- Abstracts: New tools for chloroplast genetic engineering. "Itching" for new strategies in protein engineering. The use of telomerized cells for tissue engineering
- Abstracts: Drug discovery--an operating model for a new era. Drug approval in Europe. EU's new orphan drug regulations
- Abstracts: Electricity generation by direct oxidation of glucose in mediatorless microbial fuel cells. Microbes with a mettle for bioremediation