Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function
Article Abstract:
Using classical genetics it is difficult to study modular phosphopeptide-binding domains within a family of proteins that were functionally redundant when other members of the family compensate for the product of the knocked-out gene. A chemical genetic approach is described that overcomes the limitation by using UV-activatable caged phospetides.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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An anti-infective peptide that selectively modulates the innate immune response
Article Abstract:
The immunomodulating activity of innate defense-regulator peptides (IDR-1) is due to mitogen-activated protein kinase and signaling pathways to increase the levels of monocyte chemokines. It prevents the depletion of monocytes and macrophages in the cells preventing further damage.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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