Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors
Article Abstract:
A strategy to rationally design trans-splicing adeno-associated virus (AAV) vectors was developed in a study. The method demonstrates the use of trans-splicing vectors to efficiently express a large therapeutic structural protein and could be applicable to other large therapeutic genes or large transcription regulatory elements.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Viral-mediated plant transformation gets a boost
Article Abstract:
Modifications to tobacco mosaic virus (TMV) expression vectors is described that permit efficient infection and viral replication in almost 100% of plant leaf cells. The inefficiency of viral-based systems might derive from an altered lifestyle conferred by agroinoculation, as opposed to the normal viral life cycle.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
User Contributions:
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