Engineering novel binding proteins from nonimmunoglobulin domains
Article Abstract:
The term 'scaffold' is used to describe a protein framework that could carry altered amino acids or sequence insertions that confer on protein variants different functions, usually for binding specific targets. The motivation to create alternative binding molecules derives from a desire to enable new applications where antibodies show some limitations.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Design of multivalent complexes using the barnase-barstar module
Article Abstract:
The construction, production and purification of defined dimeric and trimeric complexes are described. A multimerization system based on the very tight interaction between barnase and barstar is described.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
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Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex
Article Abstract:
Researchers from Switzerland and Germany developed a technetium labeling technology involving a novel reagent technetium-carbonyl compound with a His-tagged recombinant protein for use in cancer diagnosis.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999
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