Protein biomarker discovery and validation: The long and uncertain path to clinical utility
Article Abstract:
Advances in methods and technology enable construction of a comprehensive biomarker pipeline from six essential process components, such as, discovery, qualification, verification, research assay optimization, clinical validation and commercialization. Better understanding of the overall process of biomarker discovery and validation and of the challenges and strategies inherent in each phase should improve experimental study design, increasing efficiency of biomarker development.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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Enrichment and analysis of peptide subsets using fluorous affinity tags and mass spectrometry
Article Abstract:
The concept of 'fluorous proteomics' is introduced, whereby specific peptide subsets from samples of biological origin are tagged with perfluorinated moieties and subsequently enriched by solid-phase extraction over a flurous-functionalized stationary phase. The methodology overcomes many of the limitations of traditional bioaffinity-based enrichment strategies, while enabling new affinity enrichment schemes impossible to implement with bioaffinity reagents.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Serum proteomics profiling- a young technology begins to mature
Article Abstract:
Mass spectrometry profiling of the serum proteome is a tool with the potential to transform medicine, and rapid improvements are being made in developing methods to analyze the data produced by it. The studies provide evidence that this technology can be used to uncover proteomic expression patterns linked to a disease state.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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