Proteomics takes stem cell analyses to another level

Article Abstract:

A method is developed for assaying post-translational modifications during stem cell expansion and differentiation in a high-throughput fashion and is applied to study the growth factor-regulated differentiation of human mesenchymal stem (hMS) cells. It was established that hMS cells exposed to two distinct growth factors, epidermal growth factor (EGF) and the platelet-derived growth factors (PDGF), show different patterns of tyrosine phosphorylation (pTyr).

United States, Epidermal growth factor, Epidermal growth factors, Proteomics

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On the road to therapeutic cloning

Article Abstract:

The research based on human embryonic stem cells shows that it is possible to create human embryonic cells using the cells of the patient as a source, but many problems related to reprogramming without induction of abnormalities, control of the stem cell proliferation and other problems need to be overcome. The development of embryonic stem cells from cloned human embryos raises concerns regarding the moral and ethical issues.

Embryo

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Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype

Article Abstract:

Direct assessment of embryonic phenotypes by the tetraploid aggregation method is discussed.

Ontario, Influence, RNA

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