RISC control for gene therapy

Article Abstract:

A demonstration that transgene sensitization of immune cells could be prevented using a component of the RNA interference (RNAi) machinery is presented. By tagging the trasngene with a sequence complementary to a microRNA (miRNA) that is specific to cells of the blood lineage, it is shown that immune system priming could be circumvented.

Complications and side effects, Gene therapy, RNA interference

---

Isotype selection in antibody engineering

Article Abstract:

Study shows that antibodies of the IgG4 subclass exchange light chains in vivo, yielding bispecific products are likely to have unexpected effects in a therapeutic use. The most suitable isotype must be selected for designing antibodies for therapeutic use after considering the distinct properties of the specific isotypes.

Physiological aspects, Pharmaceutical biotechnology

---

Antibodies in the breakdown lane

Article Abstract:

An immunoglobulin G (IgG) variant that blocks FcRn function is described by binding tightly to the receptor and competing with endogenous IgGs, thereby hastening their degradation. IgG is the longest-lived and most highly expressed of the serum proteins, as befits its major functions in immunity and immunoregulation.

Immune response regulation

Similar abstracts:

• Abstracts: Contributions of property to a partnership: the proposed Section 704(c) regulations. Partnership capital interests were received for services, rules CA-8 in Mark IV Pictures
• Abstracts: Stem and progenitor cell-based therapy of the human central nervous system
• Abstracts: Using process diagrams for the graphical representation of biological networks. A partnership between biology and engineering
• Abstracts: Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor. Monoclonal antibody therapy of cancer
• Abstracts: Protecting the investors' interests. True integrity. Getting down to the OFR

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.