Standard operating procedures

Article Abstract:

Microarray Gene Expression Data Society (MGED) developed the Minimum Information About a Microarray Experiment (MIAME) specification, which has become the prototype in many respects for subsequent data-reporting guidelines in biology. MIAME is being joined by a plethora of minimum information reporting standards initiatives that cover every large-scale technology under the biological head with the shared goal of promoting data exchange and accessibility, but achieving grassroots community 'buy-in' for several of them is unlikely to be straight forward.

Innovations, Gene expression, Medical technology, Medical laboratory technology

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Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins

Article Abstract:

Luciferase-catalyzed luminescence and green fluorescent protein fluorescence were used for visualization of the tumor-specific amplification process, which revealed the locations of tumors and metastases. The findings suggest that tumor specificity and intratumoral replication were not dependent on auxotrophic mutations, vaccinia virus deficient for the thymine kinase gene or anaerobic growth conditions.

Gene mutations, Gene mutation, Metastasis, Cancer metastasis, Tumors, Tumours

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The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration

Article Abstract:

The Open Biomedical Ontologies (OBO) Foundry initiative and its guidelines on ontologies to support biomedical data integration are described. The main aim of the Foundry is to generate biomedical research data that form a single, consistent, cumulatively expanding and algorithmically tractable whole.

General services, Company systems management, Information management, Ontology

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