Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
Article Abstract:
The technique of switching domains within the constant regions of those of various antibody isotopes to improve the activities of two agonist antibodies specific for the thrombopoietin receptor (c-MPL) is described. The empirical outcomes highlight the significance of the hinge area in modulating agonist activity and the whole-IgG agonists for the c-MPL give an alternative for treatment of chronic thrombocytopenia.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2008
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Full length antibodies on display
Article Abstract:
Antibody engineering technologies has developed over the years and gained momentum with the development of methods for expressing antibodies in bacteria. The E-clonal system developed by Georgiou and his team is a bacterial system which combines expression of full-length IgG molecules and surface-displayed libraries and it simplifies many areas of antibody research.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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Antibodies
Article Abstract:
Rabbit monoclonal antibodies http://www.vectorlabs.com/ Broad specificity antibodies http://www.upstate.com/ Mouse anti-human antibodies http://www.RandDsystems.com/
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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