Systematic identification of abundant A-to-I editing sites in the human transcriptome
Article Abstract:
RNA editing by members of adenosine deaminases acting on RNA (ADAR) family leads to site-specific conversion of adenosine to inosine (A-to-I) in precursor messenger RNAs. A-to-I editing in humans primarily occurrs in noncoding regions of the RNA, typically in Alu repeats and the analysis of the large set of editing sites indicated the role of editing in controlling dsRNA stability.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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A luxRury of synthetic signals
Article Abstract:
Positive and negative selection strategies to isolate mutants of the LuxR transcription factor that could bind to and discriminate between acyl and 3-oxyl-acyl lactones (HSLs) are described. Each HSL is synthesized by a specific LuxI synthase, is secreted by bacteria and could enter other bacteria where it might bind to a specific LuxR to activate a specific genetic program.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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