A nitroxide derivative as a probe for conformational studies of short linear peptides in solution. Spectroscopic and molecular mechanics investigation
Article Abstract:
A spectroscopic investigation was undertaken to ascertain whether the ordered structure of short linear peptides' crystal state is preserved in solution. The conformational equilibria characterizing the peptides containing tryptophan (Trp) and the nitroxide derivative, Toac, was due to the rotation of the dihedral angles of the Trp side chain. Results indicate that irrespective of the polarity of the solvents used, the peptides examined maintain the basic features of the crystal state, and exhibit poor flexibility in solution.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 1998
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Peptide folding dynamics: A time-resolved study from the nanosecond to the microsecond time regime
Article Abstract:
The photophysical and conformation properties of the three analogues F0T1, F0T4, and F0T8 are reported along with the dynamics through which F0T8 collapses from an elongated helix to a compact three-dimensional (3D) arrangement of the helix-turn-helix type. The results reveal a transition from an elongated, helical conformation to a family of compact, folded structures mimicking a helix-turn-helix motif, which might represent a model of the early steps of the protein hydrophobic collapse.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2006
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Effect of peptide lipidation on membrane perturbing activity: A comparative study on two trichogin analogues
Article Abstract:
A comparative study on two synthetic analogues of the natural peptide trichogin GA IV is conducted to investigate the effect of lipidation on the membrane perturbing activity of peptaibol antibiotics. It is found that both analogues are labeled with a hydrophobic fluorescent probe, but one of them lacked the N-terminal n-octanoyl chain, present in the natural peptide.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2006
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