Kinetics of irreversible protein aggregation: Analysis of extended lumry-eyring models and implications for predicting protein shelf life
Article Abstract:
A general phenomenological kinetic model of irreversible protein aggregation in aqueous solution proceeding via non-native conformation is examined with a view toward the development of techniques top predict in vitro protein shelf life quantitatively. The results provide a basis for predicting shelf life by extrapolating high-temperature aggregation kinetics to lower-temperature, long-term storage conditions.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Interaction of protein backbone with nucleic acid bases
Article Abstract:
A theoretical study of the hydrogen-bonded (HB) complexes between a protein model and nucleic acid bases (NAB) was carried out. The results indicate that the strongest HBs between the individual NAB and the protein models involve the atoms that participate in the formation of the WC dimers.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Theoretical study of HCN and HNC neutral and charged clusters
Article Abstract:
A theoretical study of linear and cyclic clusters of hydrogen cyanide (HCN) and hydrogen isocyanide HNC is carried out. The results show that cyclic clusters are more stable than linear ones in those cases where the number of monomers considered is larger than four.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Molecular orbital calculations on the protonation of hydrogen-bonded formamide chains. Implications for peptides
- Abstracts: Vibrational band assignments for the chiral modifier cinchonidine: implications for surface studies. Surface processes induced by collisions
- Abstracts: Distribution of colloidal particles in a spherical cavity. Derivation of analytical expressions for the electrical potential distribution in lipid structures
- Abstracts: Computational analysis of the proton translocation from Asp96 to Schiff base in bacteriorhodopsin. Energy landscape of met-enkephalin and leu-enkephalin drawn using mutually orthogonal Latin squares sampling
- Abstracts: Capillary condensation of nitrogen in MCM-48 and SBA-16. Experimental evidence for pore blocking as the mechanism for nitrogen sorption hysteresis in a mesoporous material