Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide
Article Abstract:
The effects of dimethyl sulfoxide (DMSO) on a phospholipid membrane in the liquid-crystalline phase are examined by using the atomic-scale molecular dynamics (MD) simulations with realistic potentials for the modeled molecules. The results have shown that the choice of DMSO concentration for the given application is critical because the concentration has defined the specific mode of the solvent's action.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2007
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Ion transport through chemically induced pores in protein-free phospholipid membranes
Article Abstract:
Molecular dynamics simulations are carried out using realistic atomic-scale models in order to observe diffusive transmembrane ionic leakage through transient water pores induced by dimethyl sulfoxide (DMSO). The results have shown that the small amphiphilic solute DMSO is able to induce transient defects in membranes and also promote a subsequent diffusive pore-mediated transport of salt ions.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2007
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Molecular mechanism for lipid flip-flops
Article Abstract:
The molecular mechanism of pore-mediated transmembrane lipid translocation (flip-flop) obtained from atomistic molecular dynamics simulations is described. The results have shown that the exposure of lipid membranes to electric field pulses have reduced the time required for lipid flip-flops.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2007
User Contributions:
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