Single particle tracking of complex diffusion in membranes: Simulation and detection of barrier, raft, and interaction phenomena

Article Abstract:

The simulation and detection algorithms are developed for various modes of biologically relevant complex diffusive phenomena, including confined and convective diffusion, and diffusion in the presence of barriers, rafts and interparticle interactions. Few examples are illustrated to show the use of conventional vs. the new computational methods in detecting these membrane phenomena.

Membrane proteins, Cell membranes, Spectra, Optical properties, Diffusion, Diffusion (Physics)

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Millisecond association kinetics of [K.sup.} with triazacryptand-based [K.sup.} indicators measured by fluorescence correlation spectroscopy

Article Abstract:

The binding kinetics of [K.sup.} with TAC-Red and a new, longer-wavelength sensor, TAC-Crimson is quantified using fluorescence correlation spectroscopy. The rapid [K.sup.} binding kinetics with triazacryptand-based sensors support their utility for measuring changes in [K.sup.} concentrations during rapid neural signaling and ion channel gating.

Usage, Ion channels, Chemical bonds

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Fluorescence correlation spectroscopy simulations of photophysical phenomena and molecular interactions: A molecular dynamics/Monte Carlo approach

Article Abstract:

Fluorescence correlation spectroscopy (FCS) was applied to study diffusion and interactions of fluorescently labeled macromolecules in complex biological systems. The computational method is applicable for stimulating FCS measurement on system complicated by flourophore interactions or molecular crowding, and experimental protocols.

Methods, Molecular dynamics, Brownian motion, Simulated annealing (Mathematics)

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