Theoretical study of volume changes accompanying xenon-lysozyme binding: Implications for the molecular mechanism of pressure reversal of anesthesia
Article Abstract:
The change in partial molar volume (PMV) accompanying the xenon-lysozyme binding was investigated for explaining the molecular mechanism of the pressure reversal of general anesthesia. An increase of the PMV from xenon binding to the substrate binding site of lysozyme was found and the binding is suppressed by pressure while the internal binding did not change the PMV, indicating that loose packing between the anesthetics and the action site can cause the pressure reversal of general anesthesia.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2006
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Molecular information on the dissolution of polydisperse polymers: Mixtures of long and short poly(ethylene oxide)
Article Abstract:
A systematic study of the dissolution of dry, polydisperse poly(ethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, is described. The findings indicate that the low-molecular-weight/ high-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2005
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Self-consistent molecular theory of polymers in melts and solutions
Article Abstract:
A self-consistent molecular theory of conformational properties of flexible polymers in melts and solutions is proposed. This method on n-alkane molecules is demonstrated in different environments, namely, water, hexane, and in melt corresponding to poor, good, and theta condition, respectively.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2005
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